Monoclonal antibody targeting virus envelope
How to generate effective neutralizing antibodies to target infectious disease transmembrane protein antigens. A review of the technical challenges, strategies, and risks.
The genome of SARS-CoV-2 counts 29,811 nucleotides, encoding for 29 different proteins. The translation of the linear single stranded RNA conducts to the generation of the following proteome:
4 are structural proteins, S, N, M and E
16 proteins are non-structural proteins or NSP: the first 11 are encoded in ORF1a whereas the last 5 are encoded in ORF1b
9 are accessory proteins named ORF3a, ORF3b, ORF6, ORF7a, ORF7b, ORF8, ORF9b, ORF9c and ORF10.
Patient immune complications after SARS-Cov-2 infection
With more than 3,000,000 cases and 200,000 deaths, and after three months of worldwide outbreak, scientists keep on learning about COVID-19 every day.
How can people be positively diagnosed twice to COVID? Are serological diagnostic tests 100% reliable? Which part of the population is more likely to be infected?
Let’s review the latest updates on what we know about this challenging virus, and the on-going assay developments.
How to effectively monitor the humoral immune response to coronavirus infection. Secondary antibodies anti-human of great specificity and affinity.
The different therapeutic strategies being developed to tackle COVID-19 disease