Anti-histone modification epigenetic monoclonal antibodies
Histones aren’t just DNA’s neat little spools — they’re the rockstars of genome organization, turning genes on or off with a twist. But when they break free from the nucleus during stress, injury, or cell death, they go rogue. These wild histones stir up chaos, triggering inflammation and immune havoc in diseases like sepsis, lupus, and cancer.
That’s where antibodies come in: precision tools to neutralize their toxic behavior.
Targeting histones with monoclonal antibodies isn’t just smart science — it’s a bold move toward taming inflammation, rewiring immunity, and bringing clarity to complex disease mechanisms.
Anti-H3K18Ac
LO-H3K18Ac
Description: This rat antibody specifically recognizes nucleosomes whose the histone H3 is acetylated on the lysine 18
Class: monoclonal
Type: primary
Antigen: H3K18Ac
Host/Isotype : rat/IgG1 kappa
| Cancer type | Implications of H3K18Ac |
| Prostate cancer | Decreased H3K18Ac levels correlate with significantly poorer survival in patients with lung adenocarcinoma, highlighting its potential as a prognostic biomarker. |
| Kidney cancer | Lower levels of H3K18Ac also predict less favorable clinical outcomes, reinforcing its potential role in prognosis assessment |
| Breast cancer | Although H4K16Ac is more studied in this context, the importance of histone modifications in breast cancer suggests that similar marks like H3K18Ac may also have prognostic value. |
| Pancreatic Adenocarcinoma | Lower levels of H3K18Ac, particularly in combination with other marks like H3K4me2, significantly predict poor survival, highlighting their potential as prognostic biomarkers. |
Anti-H3K4me
MA-H3K4me
Description : This specific antibody recognizes nucleosomes whose the histone H3 is monomethylated on the lysine 4 without cross-reacting with mdimethyled or trimethyled H3 on the lysine 4
Class: monoclonal
Type: primary
Antigen: H3K4Me
Host/Isotype : mouse/IgG2a kappa
Anti-H3K27me3
MA-H3K27me3
Description : This specific antibody recognizes nucleosomes whose the histone H3 is trimethylated on the lysine 27 without cross-reacting with monomethyled or dimethyled H3 on the lysine 27
Class: monoclonal
Type: primary
Antigen: H3K27Me3
Host/Isotype : mouse/IgG2a kappa
| Cancer type | Expression of H3K27me3 | Prognostic implications |
|
Non-Small Cell Lung Cancer |
Low | Associated with higher invasiveness and shorter disease-free survival |
| Breast Cancer | Low | Linked to poor prognosis (though some studies report the opposite) |
| Ovarian Cancer | Low | Correlates with advanced tumor stage and worse outcomes |
| Pancreatic Cancer | Low | Associated with more aggressive disease and poor survival |
| Hepatocellular Carcinoma (HCC) | High | Correlates with vascular invasion and worse prognosis |
|
Esophageal Squamous Cell Carcinoma (ESCC) |
High | Linked to poor tumor differentiation and local invasion |
| Gastric Cancer | High | Associated with larger tumor size, poor differentiation, advanced stage, and lower overall survival |
| Acute Leukemia | Low | Predicts poor outcome, particularly in TP53 wild-type cases |
Anti-H3K36me3
MA-H3K36Me3
Description : This specific antibody recognizes nucleosomes whose the histone H3 is trimethylated on the lysine 36, without cross-reaction to mono or dimethyl group on Histone 3
Class: monoclonal
Type: primary
Antigen: H3K36Me(3)
Host/Isotype : mouse/IgG2a kappa
| Cancer type | Expression of H3K36me3 | Prognostic implication |
|
Renal Cell Carcinoma (RCC) |
Low | Associated with higher tumor grade/stage and decreased cancer-specific survival |
| Hepatocellular Carcinoma (HCC) | High | Correlates with biliary differentiation and predicts poorer 5-year disease-free and overall survival |
| Pancreatic Cancer |
Low (via SETD2 loss) |
Promotes tumor progression, possibly via upregulation of oncogenes like MYC |
| Lung Cancer |
Low (via SETD2 loss) |
Linked to increased tumor size and proliferation, suggesting role in cancer aggressiveness |
pan-Nucléosome
MA-panNucleo & panHistone
Description : This specific antibody recognizes all nucleosomes and can be used for nucleosome capture or revelation
Class: monoclonal
Type: primary
Antigen: pan-Nucleosome
Host/Isotype : mouse/IgG2a kappa
| Measuring pan-nucleosome and pan-histone levels holds great potential for advancing cancer diagnostics, prognosis, and treatment monitoring. While these measurements offer valuable information about overall chromatin structure and function, combining them with more specific analyses of histone modifications will likely yield the most comprehensive insights into cancer biology and epigenetics. |
- panH3: specific monoclonal antibody to detect Histone 3
- panH4: specific monoclonal antibody to detect Histone 4
- pan-Nucléosome: specific monoclonal antibody to detect all histones
SYnAbs S.A.
Rue Auguste Piccard, 48
I-Tech Incubator 2
B-6041 Gosselies
Belgium
BE 0637.716.206
